Early Detection Research Network

IL2RA

Aliases:
This biomarker is also known as:
  • OTTHUMP00000019031,
  • CD25,
  • IDDM10,
  • CD25 antigen,
  • IL2R,
  • TCGFR,
  • IL-2R subunit alpha,
  • IL2RA,
  • interleukin 2 receptor, alpha,
  • interleukin-2 receptor subunit alpha,
  • p55,
  • IL-2-RA,
  • IL-2 receptor subunit alpha,
  • TAC antigen,
  • IL2-RA,

Description…

The interleukin 2 receptor exists in three forms which differ in their ability to bind interleukin 2. The low affinity form of the receptor is a monomer of IL2RA, the alpha subunit. The alpha/beta subunit heterodimer, formed by IL2RA and IL2RB, is an intermediate affinity form. The alpha/beta/gamma heterotrimer formed by IL2RA, IL2RB, and IL2RG is the high affinity form. IL2RA is normally an integral membrane protein, although soluble IL2RA has been isolated. There are known alternately-spliced versions of IL2RA mRNAs, but their functions are unknown. Mutations in the IL2RA gene are associated with diabetes mellitus insulin-dependent type 10 (IDDM10). Complications of IDDM10 can adversely affect the eyes, kidneys, nerves, and blood vessels.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: IL2RA

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Curated

Overview

IL2RA is not a strong predictor of ovarian cancer.

Performance Comment

Despite many promising new markers for ovarian cancer, CA125 remains the single best biomarker in the phase II and phase III specimens tested in this study.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.