Early Detection Research Network

IL6R

Aliases:
This biomarker is also known as:
  • interleukin 6 receptor,
  • IL-6R-1,
  • CD126,
  • interleukin 6 receptor alpha subunit,
  • IL6RA,
  • IL-6 receptor subunit alpha,
  • interleukin-6 receptor subunit alpha,
  • CD126 antigen,
  • Membrane glycoprotein 80,
  • IL-6RA,
  • IL-6R subunit alpha,
  • IL6R,
  • IL-6R 1,
  • gp80,
  • IL-6R-alpha,
  • OTTHUMP00000217870,
  • MGC104991,

Description…

The interleukin 6 receptor is a protein complex consisting of two parts: the IL6R (interleukin 6 receptor) subunit and the IL6ST (interleukin 6 signal transducer) subunit. The IL6R subunit binds to IL6 (interleukin 6) with low affinity, but does not transduce a signal. The IL6ST subunit is needed for signal activation. Impaired regulation of IL6 and IL6R have been linked to many diseases, such as multiple myeloma, autoimmune diseases, and prostate cancer. Isoforms encoded by alternatively spliced transcripts have been reported. Activation of the IL6/IL6R/IL6ST complex may lead to the regulation of the immune response, acute-phase reactions, and hematopoiesis.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: IL6R

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Curated

Overview

IL6R alone has not been found to be a strong predictor of ovarian cancer.

Performance Comment

Despite many promising new markers for ovarian cancer, CA125 remains the single best biomarker in the phase II and phase III specimens tested in this study.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.