Early Detection Research Network

IMPDH2

Aliases:
This biomarker is also known as:
  • EC 1.1.1.205,
  • IMP (inosine monophosphate) dehydrogenase 2,
  • IMPD2,
  • inosine-5'-monophosphate dehydrogenase 2,
  • IMPDH2,
  • IMP dehydrogenase 2,
  • IMP (inosine 5'-monophosphate) dehydrogenase 2,
  • IMPDH 2,
  • inosine 5' phosphate dehydrogenase 2,
  • IMPD 2,
  • IMPDH,
  • inosine monophosphate dehydrogenase type II,
  • IMP oxireductase 2,
  • IMPDH-II,

Description…

The enzyme IMPDH2 catalyzes the rate-limiting step of conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed step in the de novo synthesis of guanine nucleotides. Therefore IMPDH2 is involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. It is also thought to be involvedmin the development of malignancy and the growth progression of some tumors.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Protein
HGNC Name: IMPDH2

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.