Early Detection Research Network

ITGB1

Aliases:
This biomarker is also known as:
  • VLAB,
  • very late activation protein, beta polypeptide,
  • integrin VLA-4 beta subunit,
  • MDF2,
  • CD29 antigen,
  • FNRB,
  • MSK12,
  • VLA-BETA,
  • integrin beta-1,
  • VLA-4 subunit beta,
  • GPIIA,
  • Fibronectin receptor subunit beta,
  • CD29,
  • integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12),

Description…

ITGB1 is a beta subunit of the heterodimeric integrin protein. Integrins are ubiquitously expressed adhesion molecules composed of alpha and beta subunits. In mammals, 18 alpha and 8 beta subunits have been identified. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. Several protein isoforms have been identifed, arising from alternatively spliced transcript variants.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State 3: Curated
Type: Protein
Short Name:
HGNC Name 3: ITGB1

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data is available.

Performance Comment

ITGB1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.