Early Detection Research Network

ITIH4

Aliases:
This biomarker is also known as:
  • Inter-alpha-inhibitor heavy chain 4,
  • Gp120,
  • H4P,
  • IHRP,
  • PRO1851,
  • ITI heavy chain H4,
  • ITI-HC4,
  • ITIHL1,
  • Inter-alpha-trypsin inhibitor heavy chain H4,
  • Plasma kallikrein sensitive glycoprotein 120,
  • Inter-alpha-trypsin inhibitor family heavy chain-related protein,
  • PK120,
  • PK-120,

Description…

The inter-alpha-trypsin inhibitors (ITI) are a family of plasma protease inhibitors, assembled from a light chain - bikunin, encoded by AMBP - and five homologous heavy chains (encoded by ITIH1, ITIH2, ITIH3, ITIH4, and ITIH5), contributing to extracellular matrix stability by covalent linkage to hyaluronan. ITIH4 is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of the ITIH4 gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State 3: Curated
Type: Protein
Short Name:
HGNC Name 3: ITIH4

The following organs have data associated with this biomarker…

Attributes

Phase: Three
QA State: Curated

Overview

The inter-alpha-trypsin inhibitors (ITI) are a family of plasma protease inhibitors, assembled from a light chain - bikunin, encoded by AMBP - and five homologous heavy chains (encoded by ITIH1, ITIH2, ITIH3, ITIH4, and ITIH5), contributing to extracellular matrix stability by covalent linkage to hyaluronan. ITIH molecules have been shown to play a particularly important role in inflammation and carcinogenesis. A strong correlation (p < 0.001) has been found between ITIH2 expression and estrogen receptor (ER) expression indicating that ER may be involved in the regulation of this ECM molecule.

Performance Comment

Of the 28 ovarian cancer biomarkers tested in prediagnostic specimens, from the PLCO, CA125 remains the single best biomarker for ovarian cancer and has its strongest signal within six months of diagnosis. ITIH4 alone was not a strong predictor.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.