Early Detection Research Network

KIT

Aliases:
This biomarker is also known as:
  • p145 c-kit,
  • SCF-sR,
  • C-Kit,
  • Piebald trait,
  • soluble KIT variant 1,
  • proto-oncogene c-Kit,
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog,
  • tyrosine-protein kinase Kit,
  • SCFR,
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein,
  • CD117 antigen,
  • KIT,
  • proto-oncogene tyrosine-protein kinase Kit,
  • PBT,
  • mast/stem cell growth factor receptor Kit,
  • CD117,
  • Piebald trait protein,

Description…

SCF-sR, also known as KIT, is the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. Human KIT is a tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: KIT

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Attributes

Phase: Two
QA State: Curated
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.