Early Detection Research Network

KLK2

Aliases:
This biomarker is also known as:
  • KLK2A2,
  • Glandular kallikrein-1,
  • Kallikrein-2,
  • Tissue kallikrein-2,
  • hK2,
  • hGK-1,
  • MGC12201,
  • kallikrein-related peptidase 2,
  • kallikrein 2, prostatic,
  • glandular kallikrein 2,
  • KLK2,

Description…

The glandular kallikreins are a distinct group of serine proteases with molecular masses of 25,000 to 40,000. The glandular kallikrein gene family comprises 25 to 30 highly homologous genes that encode specific proteases involved in the processing of biologically active peptides (they cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin). Several human kallikrein genes have been isolated.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Accepted
Type: Protein
HGNC Name: KLK2

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Accepted

Overview

Human glandular kallikrein (hK2) has been shown to add important information regarding the early detection and staging of prostate cancer. Together with percent free PSA (%fPSA), hK2 may help to distinguish preoperatively between pT2 and pT3 prostate cancer.

Performance Comment

hK2, hK4 and hK11 do not distinguish cases from controls in these populations.

Supporting Study Data

The following studies/protocols provide evidence supporting KLK2 indications for the Prostate…

No supporting studies or protocols found.

Organ-Specific Protocols

No organ-specific protocols defined.

Organ-Specific Publications

No organ-specific publications defined.

Organ-Specific Resources

No organ-specific resources defined.

No associated publications found.