Early Detection Research Network

KLK8

Aliases:
This biomarker is also known as:
  • ovasin,
  • PRSS19,
  • Tumor-associated differentially expressed gene 14 protein,
  • NP,
  • Serine protease TADG-14,
  • NRPN,
  • hK8,
  • Serine protease 19,
  • TADG14,
  • kallikrein-related peptidase 8,
  • Ovasin,
  • HNP,
  • KLK8,
  • neuropsin,
  • kallikrein 8 (neuropsin/ovasin),
  • Neuropsin,

Description…

KLK8, a member of the kallikrein subgroup of serine proteases, is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Kallikreins have been implicated in carcinogenesis, and some have potential as novel cancer and other disease biomarkers. KLK8 is one of fifteen kallikrein subfamily members located in a cluster on chromosome 19. The four isoforms of KLK8 are a result of alternate splicing of the gene. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: KLK8

The following organs have data associated with this biomarker…

Attributes

Phase: Three
QA State: Curated

Overview

KLK8 alone was not shown to be a strong predictor of ovarian cancer.

Performance Comment

Despite many promising new markers for ovarian cancer, CA125 remains the single best biomarker in the phase II and phase III specimens tested in this study.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.