Early Detection Research Network

Laxman 7-marker panel for prostate cancer

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    Description…

    This 7-marker multiplex panel of urine transcripts outperforms PCA3 transcript alone for the detection of prostate cancer. The panel consists of PCA3, AMACR, ERG, GP73 (GOLPH2), SPINK1, TFF3, and TMPRSS2:ERG fusion.

    Datasets

    There are no datasets associated with this biomarker.

    Attributes
    QA State: Curated
    Short Name:
    HGNC Name:

    Panel Details

    The following organs have data associated with this biomarker…

    Attributes

    Phase: Two
    QA State: Curated

    Overview

    This 7-marker panel has been shown to outperform serum PSA or PCA3 assays alone when used on sedimented urine from patients considered for prostate biopsy or prostatectomy.

    Performance Comment

    The area under the receiver-operating characteristic curve was 0.758 for the multiplexed model versus 0.662 for PCA3 alone (P = 0.003). The sensitivity and specificity for the multiplexed model were 65.9% and 76.0%, respectively, and the positive and negative predictive values were 79.8% and 60.8%, respectively.

    This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

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