Early Detection Research Network

LHB

Aliases:
This biomarker is also known as:
  • Lutropin,
  • CGB4,
  • LHB,
  • LH-B,
  • LSH-B,
  • luteinizing hormone beta subunit,
  • hLHB,
  • interstitial cell stimulating hormone, beta chain,
  • Luteinizing hormone subunit beta,
  • lutropin subunit beta,
  • Lutropin beta chain,
  • LSH-beta,
  • luteinizing hormone beta polypeptide,

Description…

The pituitary glycoprotein hormone family includes follicle stimulating hormone (FSH), luteinizing hormone (LH), chorionic gonadotropin (CG), and thyroid-stimulating hormone (TSH). All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. LHB, the beta subunit of luteinizing hormone, confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: LHB

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Curated

Overview

LHB alone was not shown to be a strong predictor of ovarian cancer.

Performance Comment

Despite many promising new markers for ovarian cancer, CA125 remains the single best biomarker in the phase II and phase III specimens tested in this study.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.