Early Detection Research Network

LTBP2

Aliases:
This biomarker is also known as:
  • LTBP2,
  • chromosome 14 open reading frame 141,
  • C14orf141,
  • Latent-transforming growth factor beta-binding protein 2,
  • LTBP3,
  • GLC3D,
  • LTBP-2,
  • MSTP031,
  • latent transforming growth factor beta binding protein 2,

Description…

LTBP2, the largest member of the latent transforming growth factor (TGF)-beta binding protein family, possesses unique regions and is most similar to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. LTBP2 forms part of the large latent transforming growth factor beta precursor complex; removal is essential for activation of complex. It is expressed in lung, weakly expressed in heart, placenta, liver and skeletal muscle.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: LTBP2

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Under Review

Overview

No additional ovarian data available.

Performance Comment

LTBP2 was one of 50 tumor vasculature-associated genes with transmembrane or secreted protein products identified through expression profiling of ovarian cancer vascular cells. These 50 tumor vascular markers (TVMs) also had low or no expression in normal tissues. LTBP2 was not in the group of 13 selected for further validation.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.