Early Detection Research Network

LZTS1

Aliases:
This biomarker is also known as:
  • leucine zipper, putative tumor suppressor 1,
  • Fez1,
  • LZTS1,
  • FEZ1,
  • Q9Y250,
  • leucine zipper putative tumor suppressor 1,
  • F37,
  • F37/Esophageal cancer-related gene-coding leucine-zipper motif,
  • F37/esophageal cancer-related gene-coding leucine-zipper motif,

Description…

LZTS1 is a tumor suppressor protein that is widely expressed in normal tissues. It is involved in regulating cell growth and is also thought to interact with the active CDC2-cyclin B1 complex and contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer, and this gene is located on 8p22.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: LZTS1

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Under Review

Overview

LZTS1 may be considered for further preclinical testing as a tumor biomarker.

Performance Comment

LZTS1 was overexpressed in ovarian cancer relative to normal ovary and relative to a panel of normal organs. LZTS1 was found in small and larger blood vessels. FZD10 showed limited or no expression by qRT-PCR in normal tissues.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.