Early Detection Research Network

MAPK14

Aliases:
This biomarker is also known as:
  • RK,
  • MAP kinase p38 alpha,
  • SAPK2A,
  • p38 MAP kinase,
  • CSPB1,
  • mitogen-activated protein kinase 14,
  • PRKM15,
  • Csaids binding protein,
  • p38alpha Exip,
  • MAX-interacting protein 2,
  • cytokine suppressive anti-inflammatory drug-binding protein,
  • p38,
  • MAP kinase MXI2,
  • cytokine suppressive anti-inflammatory drug binding protein,
  • Mitogen-activated protein kinase p38 alpha,
  • p38 mitogen activated protein kinase,
  • EXIP,
  • Cytokine suppressive anti-inflammatory drug-binding protein,
  • Mxi2,
  • CSBP1,
  • MAPK 14,
  • stress-activated protein kinase 2A,
  • MAP kinase 14,
  • mitogen-activated protein kinase p38 alpha,
  • p38ALPHA,
  • MAP kinase Mxi2,
  • MXI2,
  • CSAID-binding protein,
  • MAPK14,
  • CSBP2,
  • CSBP,
  • PRKM14,
  • EC 2.7.11.24,
  • SAPK2a,
  • Stress-activated protein kinase 2a,

Description…

From NCBI Gene: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Protein
HGNC Name: MAPK14

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.