Early Detection Research Network

Massion 4-marker FISH panel for lung cancer

Aliases:
This biomarker is also known as:
  • Massion 4-marker FISH panel for lung cancer,

Description…

The combination of these 4 probes, TP63, MYC, CEP3, and CEP6, offered a sensitivity of 82% for lung cancer and a specificity of 58%. These results indicate that specific cytogenetic alterations present in preinvasive lung lesions are closely associated with the diagnosis of lung cancer and may therefore have value in assessing lung cancer risk.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
HGNC Name:

Panel Details

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Curated

Overview

In this study, we found that the high frequency of non-coding centromeric alterations (CEP3 and CEP 6) was independently associated with a diagnosis of lung cancer (Table 2), and therefore although not specifically linked to tumorigenesis, it is probably part of the genomic instability coming along with the disease process.

Performance Comment

The odds of having lung cancer given that a preinvasive lesion had gain for genomic regions increased from 4.23 (1.21–14.8, 95%CI) when 1 or 2 markers of 4 (CEP3, TTP63, CEP6, MYC) were abnormal to 11 (2.63–45.9, 95%CI) when 3 or 4 markers showed elevated copy numbers.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

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