Early Detection Research Network

MCAM

Aliases:
This biomarker is also known as:
  • melanoma-associated antigen MUC18,
  • Melanoma cell adhesion molecule,
  • S-endo 1 endothelial-associated antigen,
  • CD146,
  • CD146 antigen,
  • cell surface glycoprotein P1H12,
  • melanoma cell adhesion molecule,
  • Cell surface glycoprotein P1H12,
  • Gicerin,
  • Melanoma-associated antigen MUC18,
  • MUC18,
  • Melanoma-associated antigen A32,
  • cell surface glycoprotein MUC18,
  • melanoma adhesion molecule,
  • melanoma-associated antigen A32,

Description…

From UniProtKB/Swiss-Prot: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State 3: Curated
Type: Gene
Short Name:
HGNC Name 3: MCAM

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Curated

Overview

No additional data available.

Performance Comment

MCAM is one of eight genes on a panel of differentially methylated genes from normal and OSCC clinical samples from patients with heterogenous risk profiles chosen for further validation. The eight genes are: HOXA9, NID2, GATA4, KIF1A, EDNRB, MCAM, DCC, and CALCA.

Attributes

Phase: One
QA State: Under Review

Overview

Performance Comment

Attributes

Phase: One
QA State: Under Review

Overview

Performance Comment

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.