Early Detection Research Network

MGMT

Aliases:
This biomarker is also known as:
  • MGMT,
  • O6-methylguanine-DNA methyltransferase,
  • EC 2.1.1.63,
  • O-6-methylguanine-DNA-alkyltransferase,
  • methylguanine-DNA methyltransferase,
  • O-6-methylguanine-DNA methyltransferase,
  • 6-O-methylguanine-DNA methyltransferase,
  • methylated-DNA--protein-cysteine methyltransferase,

Description…

MGMT is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. It repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Genomic
HGNC Name: MGMT

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.