Early Detection Research Network


This biomarker is also known as:
  • MIR-486,
  • hsa-miR-486-5p,
  • MIR486-5p,
  • 486-5p,
  • MIR486,


From NCBI Gene: MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. miRNAs bind to complementary sequences in the 3' UTR of multiple target mRNAs, usually silencing the targeted mRNA. miRNAs may trigger the cleavage of their target molecules or act as translational repressors. miRNAs are thought to target approximately 60% of all genes and are able to repress hundreds of targets each. MIR486-5p is a variant of MIR486.


There are no datasets associated with this biomarker.

QA State: Curated
Type: Genomic
HGNC Name:

The following organs have data associated with this biomarker…


Phase: One
QA State: Curated


MIR486-5p has been identified as one of the most downregulated miRNAs in lung cancer.

Performance Comment

MIR486-5p is one of four members of a panel investigated as potential plasma biomarkers for non-small-cell lung cancer (NSCLC). The four members of the panel are MIR486-5p, MIR21, MIR126, MIR210.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.