Early Detection Research Network

Ovary

Matrix metalloproteinases (MMPs) play key roles in tumorigenesis. A recent study has shown that epithelial expression of MMP7 is higher in serous ovarian tumors than mucinous ovarian tumors, stromal expression of MMP7 is higher in serous ovarian tumors, and that alterations in MMP7 have been found in malignant serous ovarian tumors, while benign and borderline ovarian tumors share similar expression profiles.
http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/65/83
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Of the 28 ovarian cancer biomarkers tested in prediagnostic specimens, from the PLCO, CA125 remains the single best biomarker for ovarian cancer and has its strongest signal within six months of diagnosis. MMP7 alone was not a strong predictor.
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