Early Detection Research Network


This biomarker is also known as:
  • MSLN,
  • Soluble Mesothelin Related Peptide,
  • SMRP,


Soluble mesothelin-related protein (SMRP) is related to the mesothelin family of molecules. It is overexpressed in ovarian cancer, malignant pleural mesothelioma (MPM), and certain other cancers. One hypothesis for the origin of SMRP is that this mesothelin-like molecule was released from tumor cells into culture supernatants, sera, and malignant effusions from certain tumors. Another hypothesis is that SMRP is actually a proteolytically cleaved fragment of membrane-bound mesothelin. Currently SMRP is considered to be an isoform of mesothelin (MSLN). UniprotKB/SwissProt lists isoform 3 of human mesothelin (identifier Q13421-2) as SMRP.


There are no datasets associated with this biomarker.

QA State: Curated
Type: Protein

The following organs have data associated with this biomarker…


Phase: One
QA State: Under Review


Differentially expressed mesothelial protein. May comprise a biomarker panel with SPP1 (osteopontin). SMRP can be assayed using MESOMARK, a 2-step immunoenzymatic assay in an ELISA format with a 6-point calibration curve. The MESOMARK assay may be useful for the detection and management of mesothelioma.

Performance Comment

SMRP is a promising biomarker for malignant pleural mesothelioma (MPM) in both serum and pleural effusion fluid.


Phase: Two
QA State: Under Review


Performance Comment

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.