Early Detection Research Network

CA15-3

Aliases:
This biomarker is also known as:
  • MUC-1,
  • ADMCKD,
  • Tumor-Associated Epithelial Membrane Antigen,
  • ADMCKD1,
  • MCD,
  • Medullary Cystic Kidney Disease, Autosomal Dominant,
  • MUC-1/SEC,
  • MUC1,
  • Carcinoma-Associated Mucin,
  • CA15-3,
  • Medullary Cystic Kidney Disease 1 (Autosomal Dominant),
  • Mucin-1,
  • Krebs Von Den Lungen-6,
  • Breast Carcinoma-Associated Antigen DF3,
  • DF3 Antigen,
  • MAM6,
  • PEM,
  • MUC-1/X,
  • CA15.3,
  • Cancer Antigen 15-3,
  • Mucin 1, Cell Surface Associated,
  • MCKD1,
  • PEMT,
  • Tumor-Associated Mucin,
  • EMA,
  • MCKD,
  • Mucin 1, Transmembrane,
  • H23AG,
  • Tumor Associated Epithelial Mucin,
  • H23 Antigen,
  • CD227 Antigen,
  • Episialin,
  • Peanut-Reactive Urinary Mucin,
  • Polymorphic Epithelial Mucin,
  • CD227,
  • KL-6,
  • CA 15-3,
  • PUM,
  • MUC1/ZD,

Description…

From NCBI Gene: This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

Attributes
QA State: Accepted
Type: Protein
HGNC Name: MUC1

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Curated
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Attributes

Phase: Two
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Attributes

Phase: Three
QA State: Accepted

Overview

CA15-3 may be a molecular marker for ovarian cancer. Literature suggests that the concomitant measurement of CA15-3 with CA125 could be advantageous in the pre-operative discrimination of benign and malignant ovarian tumors.

Performance Comment

Of the 28 ovarian cancer biomarkers tested in prediagnostic specimens, from the PLCO, CA125 remains the the single best biomarker for ovarian cancer and has its strongest signal within six months of diagnosis. CA15-3 alone was not a strong predictor.

Supporting Study Data

The following studies/protocols provide evidence supporting CA15-3 indications for the Ovary…

No supporting studies or protocols found.

Organ-Specific Protocols

No organ-specific protocols defined.

Organ-Specific Publications

Organ-Specific Resources

No organ-specific resources defined.

Attributes

Phase: One
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.