Early Detection Research Network


This biomarker is also known as:
  • Dilute myosin heavy chain, non-muscle,
  • Myosin-12,
  • myosin VA (heavy polypeptide 12, myoxin),
  • MYO5,
  • myosin V,
  • myosin-Va,
  • myosin VA (heavy chain 12, myoxin),
  • Myoxin,
  • unconventional myosin-Va,
  • MYO5A,
  • dilute myosin heavy chain, non-muscle,
  • Myosin heavy chain 12,
  • MYR12,
  • GS1,
  • myosin-12,
  • myosin, heavy polypeptide kinase,
  • myoxin,
  • MYH12,


The MYO5A gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. The MYO5A protein functions as a processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. MYO5A is also involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. Different isoforms, encoded by alternatively spliced transcript variants, have been reported.


There are no datasets associated with this biomarker.

QA State: Curated
Type: Protein

The following organs have data associated with this biomarker…


Phase: Two
QA State: Under Review


No additional breast data available.

Performance Comment

MYO5A was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.