Early Detection Research Network

NELL1

Aliases:
This biomarker is also known as:
  • nel-like 1,
  • NRP1,
  • NELL1,
  • Nel-related protein 1,
  • Protein kinase C-binding protein NELL1,
  • NEL-like protein 1,

Description…

NELL1 is a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Accepted
Type: Genomic
HGNC Name: NELL1

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Accepted

Overview

Esphageal adenocarcinoma risk in Barrett's esophagus is increased 30- to 125- fold versus the general population. Among all Barrett's esophagus patients neoplastic progression occurs only once per 200 patient-years. Molecular markers (individual or in panel) would be useful to risk-stratify patients for more efficient surveillance endoscopy and to improve the early detection of progression.

Performance Comment

Promoter hypermethylation of NELL1 occurs early during Barrett's-associated esophageal neoplastic progression, and is a potential biomarker of poor prognosis in early-stage esophageal adenocarcinoma. Studies are ongoing.

Supporting Study Data

The following studies/protocols provide evidence supporting NELL1 indications for the Esophagus…

No supporting studies or protocols found.

Organ-Specific Protocols

No organ-specific protocols defined.

Organ-Specific Publications

No organ-specific publications defined.

Organ-Specific Resources

No organ-specific resources defined.

No associated publications found.