Early Detection Research Network

NID2

Aliases:
This biomarker is also known as:
  • osteonidogen,
  • Osteonidogen,
  • nidogen 2 (osteonidogen),
  • NID-2,
  • nidogen-2,
  • NID2,

Description…

NID2 is a member of the nidogen family of basement membrane proteins. It is a cell adhesion glycoprotein that binds collagens I and IV and laminin. NID2 may be involved in maintaining the structure of the basement membrane, and in cell-extracellular matrix interactions.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Gene
HGNC Name: NID2

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Curated

Overview

HOXA9 and NID2 have been identified as novel differentially methylated genes in oral squamous cell carcinoma. These genes were also shown to have significantly higher methylation levels in tumor than normal oral mucosa, as seen by ROC analysis of head and neck squamous cell carcinoma samples.

Performance Comment

HOXA9 and NID2 are promising oral squamous cell carcinoma biomarkers that should be studied on tissue, saliva and serum from larger cohorts.  HOXA9 and NID2 were chosen for further study because they were the only candidate genes that had an AUC value equal to or higher than 0.75,  and 100% specificity and sensitivity higher than 70%.

Attributes

Phase: One
QA State: Under Review

Overview

NID2 is a biomarker for ovarian cancer which correlates closely with CA125. NID2 was elevated in serum of patients with ovarian carcinoma, compared to patients with benign gynecological diseases and normal controls.

Performance Comment

NID2 is a biomarker for ovarian cancer which correlates closely with CA125. NID2 was elevated in serum of patients with ovarian carcinoma, compared to patients with benign gynecological diseases and normal controls.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.