Early Detection Research Network


This biomarker is also known as:
  • Peptidyl-cysteine S-nitrosylase NOS1,
  • Neuronal NOS,
  • N-NOS,
  • NOS,
  • Constitutive NOS,
  • constitutive NOS,
  • NC-NOS,
  • nitric oxide synthase, brain,
  • EC,
  • IHPS1,
  • neuronal NOS,
  • nNOS,
  • bNOS,
  • peptidyl-cysteine S-nitrosylase NOS1,
  • nitric oxide synthase 1 (neuronal),
  • NOS type I,


NOS1, or nitric oxide synthase 1 (neuronal), along with inducible nitric oxide synthase (NOS2) and endothelial nitric oxide synthase (NOS3), catalyze the generation of nitric oxide and L-citrulline from L-arginine and molecular oxygen. Nitric oxide is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter. NOS1 also displays antimicrobial and antitumoral activities.


There are no datasets associated with this biomarker.

QA State 3: Curated
Type: Protein
Short Name:
HGNC Name 3: NOS1

The following organs have data associated with this biomarker…


Phase: Two
QA State: Under Review


No additional breast data available.

Performance Comment

NOS1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.