Early Detection Research Network

OVA1

Aliases:
This biomarker is also known as:
  • OVA1,

Description…

The OVA1 diagnostic test is comprised of five biomarkers: CA125, transthyretin (prealbumin), apolipprotein A1 (Apo A-1), beta-2 microglobulin, and transferrin. OVA1 is an In Vitro Diagnostic Multivariate Index Assay (IVDMIA) of Proteomic Biomarkers test that analyzes the serum levels of these five proteomic biomarkers. OVA1 is the first FDA approved test for assessing ovarian cancer risk in women previously diagnosed with an ovarian mass, and already scheduled for surgery. The OVA1 algorithm combines the results of these levels with information on the menopause status of the patient to classify the patient into a low- or high-risk group. The results of the OVA1 test can help determine patients needing referral to a gynecologic oncologist for their surgery.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
HGNC Name:

Panel Details

The following organs have data associated with this biomarker…

Attributes

Phase: Three
QA State: Curated

Overview

OVA1 is intended for women 18 years old and older who have a previously identified ovarian mass. It is not intended to be used as a widespread screening tool or for diagnostic purposes. The OVA1 test is used in conjunction with other clinical and radiographic data to determine referral to a gynecologic oncologist.

Performance Comment

Clinical tests of OVA1 versus CA125 alone showed that OVA1 correctly predicted 94% of malignancies in a sample of 516 patients, versus 77% for CA125. OVA1 also increased accurate prediction in premenopausal women to 91%, versus fewer than 58% with CA125. OVA1 does have a two times greater chance than CA125 of predicting a malignancy where there is none (false positive). However, the patients using the OVA1 test are all scheduled for surgery to remove an ovarian mass, and the slightly higher false positive rate simply raises the probability that a gynecologic oncologist will perform the surgery.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.