Early Detection Research Network

PARK7

Aliases:
This biomarker is also known as:
  • PARK7,
  • Oncogene DJ-1,
  • DJ1,
  • Protein DJ-1,
  • Parkinson disease (autosomal recessive, early onset) 7,
  • Parkinson disease protein 7,
  • DJ-1,

Description…

DJ-1, also known as PARK-7, belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. DJ-1 is highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart and is detected at slightly lower levels in placenta and brain.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Accepted
Type: Protein
HGNC Name: PARK7

The following organs have data associated with this biomarker…

Attributes

Phase: Three
QA State: Under Review

Overview

Validation study was conducted to determine whether DJ-1 antigens are associated with autoantibodies in sera collected at the pre-symptomatic stage of lung cancer.

Performance Comment

Supporting Study Data

The following studies/protocols provide evidence supporting PARK7 indications for the Lung…

No supporting studies or protocols found.

Organ-Specific Protocols

No organ-specific protocols defined.

Organ-Specific Publications

No organ-specific publications defined.

Organ-Specific Resources

No organ-specific resources defined.

No associated publications found.