Early Detection Research Network


This biomarker is also known as:
  • DJ1,
  • Oncogene DJ-1,
  • Parkinson disease (autosomal recessive, early onset) 7,
  • Parkinson disease protein 7,
  • Protein DJ-1,
  • DJ-1,


DJ-1, also known as PARK-7, belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. DJ-1 is highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart and is detected at slightly lower levels in placenta and brain.


There are no datasets associated with this biomarker.

QA State 3: Accepted
Type: Protein
Short Name:
HGNC Name 3: PARK7

The following organs have data associated with this biomarker…


Phase: Three
QA State: Under Review


Validation study was conducted to determine whether DJ-1 antigens are associated with autoantibodies in sera collected at the pre-symptomatic stage of lung cancer.

Performance Comment

Supporting Study Data

The following studies/protocols provide evidence supporting PARK7 indications for the Lung…

Validation of Protein Markers for Lung Cancer Using CARET Sera and Proteomics Techniques

1.1 To validate the finding from pilot studies with CARET sera of autoantibodies to annexins I and II and PGP9.5 as potential biomarkers for lung cancers before the clinical diagnosis, evaluating sensitivity and specificity by time before diagnosis, treatment arm, gender, histologic type, and smoking status. 1.2 To determine whether a pattern of occurrence of autoantibodies in lung cancer sera may be diagnostic of lung cancer that is not dependent on the occurrence of any particular autoantibody. 1.3 To compare the findings for individual biomarker candidates and combinations of biomarker candidates in participants who were current smokers versus former smokers.

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Biomarker Characteristics Summary

No statistics found.

Decision Rule

No extra decision rule information available

Additional Study-Specific Protocols
Study-Specific Publications

No study-specific publications defined.

Study-Specific Resources

No study-specific resources defined.

Organ-Specific Protocols

No organ-specific protocols defined.

Organ-Specific Publications

No organ-specific publications defined.

Organ-Specific Resources

No organ-specific resources defined.