Early Detection Research Network

POLQ

Aliases:
This biomarker is also known as:
  • PRO0327,
  • POLH,
  • DKFZp781A0112,
  • DNA polymerase theta,
  • POLQ,
  • polymerase (DNA directed), theta,
  • DNA polymerase eta,

Description…

POLQ belongs to the DNA polymerase type-A family and has one helicase ATP-binding domain and one helicase C-terminal domain. POLQ has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. POLQ exhibites a single-stranded DNA-dependent ATPase activity and could be involved in the repair of interstrand cross-links. It is highly expressed in testis. There are two isoforms of POLQ produced by alternative splicing.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Protein
HGNC Name: POLQ

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.