Early Detection Research Network


This biomarker is also known as:
  • nuclear protein containing WW domain 38 kD,
  • SHS,
  • polyglutamine-binding protein 1,
  • PQBP-1,
  • NPW38,
  • MRX55,
  • mental retardation, X-linked 55,
  • polyglutamine binding protein 1,
  • MRXS8,
  • Polyglutamine tract-binding protein 1,
  • Npw38,
  • RENS1,
  • PQBP1,
  • MRXS3,
  • Sutherland-Haan X-linked mental retardation syndrome,
  • 38 kDa nuclear protein containing a WW domain,
  • polyglutamine tract-binding protein 1,


From NCBI Gene: This gene encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW domain. Mutations in this gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.[provided by RefSeq, Nov 2009]


There are no datasets associated with this biomarker.

QA State: Curated
Type: Gene

The following organs have data associated with this biomarker…


Phase: One
QA State: Curated


No additional prostate data available.

Performance Comment

Significance Analysis of Microarray (SAM) was used to develop a 7-gene classifier. The overall prediction accuracy and sensitivity is 71% and 76%, respectively. The inclusion of the Gleason sum to the seven-gene classifier raised the prediction accuracy and sensitivity to 83% and 76% respectively This prognostic signature is closely associated with biochemical recurrence in patients after radical prostatectomy. The seven genes are: RRAGD, PQBP1, HIST1H2BC, ALDH1A2, TRIM22, RBPMS, HSPB8.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.