Early Detection Research Network

PRKCI

Aliases:
This biomarker is also known as:
  • EC 2.7.11.13,
  • Atypical protein kinase C-lambda/iota,
  • nPKC-iota,
  • protein kinase C iota type,
  • PRKC-lambda/iota,
  • PKCI,
  • protein kinase C, iota,
  • PRKCI,
  • aPKC-lambda/iota,
  • DXS1179E,
  • atypical protein kinase C-lambda/iota,

Description…

PRKCI is a member of the protein kinase C (PKC) family of serine/threonine protein kinases. It is a calcium- and diacylglycerol-independent serine/threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: PRKCI

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Curated
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.