Early Detection Research Network

PTPRE

Aliases:
This biomarker is also known as:
  • protein tyrosine phosphatase, receptor type, epsilon polypeptide,
  • PTPRE,
  • PTPE,
  • HPTPE,
  • receptor-type tyrosine-protein phosphatase epsilon,
  • protein tyrosine phosphatase, receptor type, E,
  • Protein-tyrosine phosphatase epsilon,
  • R-PTP-EPSILON,
  • EC 3.1.3.48,
  • R-PTP-epsilon,

Description…

PTPRE is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. The PTPRE gene encodes two isoforms, one of which is a receptor-type PTP, and the other which is not a receptor-type PTP. Both isoforms act as negative regulators of FceRI-mediated signal transduction leading to cytokine production and degranulation.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: PTPRE

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

PTPRE was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.