Early Detection Research Network

PXN

Aliases:
This biomarker is also known as:
  • Paxillin,
  • PXN,

Description…

From NCBI Entrez Gene: This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: PXN

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Curated

Overview

PXN, or paxillin, has been found to be immunoreactive with plasma from patients with advanced-stage lung cancers. (Zhong et. al. Am J Respir Crit Care Med. 2005 Nov 15;172(10):1308-14. Epub 2005 Aug 18.)

Performance Comment

Measurements of the five most predictive antibody markers in 46 cases and controls were combined in a logistic regression model that yielded area under the receiver operating characteristics curve of 0.99; leave-one-out validation achieved 91.3% sensitivity and 91.3% specificity. (Zhong et al., J Thorac Oncol. 2006 Jul;1(6):513-9) The five antibody markers are PXN, EXOC6B (known as SEC15L2 in the publication), BAC clone RP11-499F19, XRCC5, and MALAT1.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.