Early Detection Research Network

RARB

Aliases:
This biomarker is also known as:
  • retinoic acid receptor beta,
  • retinoic acid receptor beta variant 1,
  • Nuclear receptor subfamily 1 group B member 2,
  • retinoic acid receptor beta 5,
  • HAP,
  • RAR-beta,
  • hepatitis B virus activated protein,
  • retinoic acid receptor beta 2,
  • NR1B2,
  • HBV-activated protein,
  • retinoic acid receptor, beta,
  • RAR-epsilon,
  • retinoic acid receptor beta variant 2,
  • retinoic acid receptor beta 4,
  • RARB,
  • retinoic acid receptor, beta polypeptide,
  • RRB2,

Description…

The RARB gene encodes the retinoic acid receptor beta. It is a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators (NRB1 class). These receptors bind to their targets as heterodimers in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. This receptor localizes to the cytoplasm and to subnuclear compartments where it binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that the RARB protein limits growth of many cell types by regulating gene expression. There are three distinct RAR subtypes; RARalpha, RARbeta and RARgamma. RARalpha is present in most tissue types, whereas RARbeta and RARgamma expression is more selective. Two full length transcript variants have been verified. A third is possible.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Gene
HGNC Name: RARB

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.