Early Detection Research Network


This biomarker is also known as:
  • rho cDNA clone 12,
  • Rho cDNA clone 12,
  • Aplysia ras-related homolog 12,
  • RHOA,
  • small GTP binding protein RhoA,
  • oncogene RHO H12,
  • RhoA,
  • RHOH12,
  • ARH12,
  • ras homolog family member A,
  • ARHA,
  • h12,
  • transforming protein RhoA,
  • ras homolog gene family, member A,
  • RHO12,
  • Rho12,


RHOA is a member of the small GTPase superfamily. RHO family GTPases are involved in many basic cellular processes that influence cell proliferation, differentiation, motility, adhesion, survival, or secretion. RHOA regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.


There are no datasets associated with this biomarker.

QA State: Curated
Type: Protein

The following organs have data associated with this biomarker…


Phase: Two
QA State: Under Review


RHOA has been shown to be involved in hypoxia-inducible factor-mediated RHOA expression and signaling in breast cancer cells.

Performance Comment

RHOA was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.