Early Detection Research Network


This biomarker is also known as:
  • ring finger protein 113A,
  • zinc finger protein 183 (RING finger, C3HC4 type),
  • Cwc24,
  • ZNF183,
  • Zinc finger protein 183,
  • RNF113A,
  • RING finger protein 113A,
  • RNF113,


RNF113A is a member of the RNF family, or RING-type zinc finger proteins. The RNF proteins are a subset of the larger family of zinc finger proteins. Members of the RNF family have an enzyme activity known as E3 ubiquitin-protein ligase which targets other proteins to be degraded within cells. RNF113A contains a C3H1-type zinc finger domain and a C3HC4 Ring-type (Really Interesting New Gene-type) zinc finger domain. The Ring-type zinc finger domain is present in various tumor suppressors, DNA repair genes and cytokine receptor-associated molecules, and is implicated in mediating protein-protein interactions.


There are no datasets associated with this biomarker.

QA State: Curated
Type: Protein
HGNC Name: RNF113A

The following organs have data associated with this biomarker…


Phase: Two
QA State: Under Review


RNF113A is a RING-type zinc finger protein. Several RING-type zinc finger proteins act as tumor suppressors. BRCA1 is also a RING-type zinc finger protein, with the same C3HC4 Ring-type zinc finger domain as RNF113A. Mutations in the tumor suppressor BRCA1 are widely known to contribute to the development of breast cancer.

Performance Comment

RNF113A was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.