Early Detection Research Network


This biomarker is also known as:
  • NEM/1CHD4,
  • p40,
  • LRP/LR,
  • LAMR1,
  • ribosomal protein SA,
  • LBP,
  • 67kD, ribosomal protein SA,
  • LamR,
  • Multidrug resistance-associated protein MGr1-Ag,
  • 34/67 kDa laminin receptor,
  • RPSA,
  • LBP/p40,
  • Colon carcinoma laminin-binding protein,
  • LAMBR,
  • 67LR,
  • 37LRP,
  • RSSA,
  • laminin receptor 1,
  • LRP,
  • 40S ribosomal protein SA,
  • Laminin-binding protein precursor p40,
  • laminin receptor 1 (67kD, ribosomal protein SA),


Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. The amino acid sequence of laminin receptor 1 is highly through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Cell-adhesive protein LAMR1 plays an important role in the processes of cancer proliferation, invasion and metastasis. LAMR1 antigens have been found to be targets of autoantibodies in subjects newly diagnosed with lung cancer.

QA State: Accepted
Type: Protein

The following organs have data associated with this biomarker…


Phase: Three
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.