Early Detection Research Network


This biomarker is also known as:
  • CBFA3,
  • Oncogene AML-2,
  • CBF-alpha-3,
  • Core-binding factor subunit alpha-3,
  • PEBP2-alpha C,
  • RUNX3,
  • Runt-related transcription factor 3,
  • SL3/AKV core-binding factor alpha C subunit,
  • Acute myeloid leukemia 2 protein,
  • Polyomavirus enhancer-binding protein 2 alpha C subunit,
  • AML2,
  • SL3-3 enhancer factor 1 alpha C subunit,
  • PEA2-alpha C,
  • PEBP2A3,


RUNX3 is a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

QA State: Accepted
Type: Genomic

The following organs have data associated with this biomarker…


Phase: Two
QA State: Accepted


Esophageal adenocarcinoma risk in Barrett's esophagus is increased 30- to 125- fold versus the general population. Among all Barrett's esophagus patients neoplastic progression occurs only once per 200 patient-years. Molecular markers (individual or in panel) would be useful to risk-stratify patients for more efficient surveillance endoscopy and to improve the early detection of progression.

Performance Comment

p16, RUNX3, and TMEFF2 (HPP1) display increasing methylation frequencies in Barrett's esophagus versus esophageal adenocarcinoma. These markers are being further investigated for potential utility in screening Barrett's patients likely to develop esophageal adenocarcinoma.

Supporting Study Data

The following studies/protocols provide evidence supporting RUNX3 indications for the Esophagus…

No supporting studies or protocols found.

Organ-Specific Protocols

No organ-specific protocols defined.

Organ-Specific Publications

No organ-specific publications defined.

Organ-Specific Resources

No organ-specific resources defined.


Phase: One
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.