Early Detection Research Network


This biomarker is also known as:
  • leukocyte surface antigen Leu-8,
  • CD62L,
  • CD62L antigen,
  • lymph node homing receptor,
  • selectin L,
  • CD62 antigen-like family member L,
  • Leukocyte adhesion molecule 1,
  • leukocyte-endothelial cell adhesion molecule 1,
  • PLNHR,
  • Leu-8,
  • LEU8,
  • pln homing receptor,
  • Leukocyte-endothelial cell adhesion molecule 1,
  • sL-selectin,
  • LNHR,
  • Leukocyte surface antigen Leu-8,
  • LSEL,
  • hLHRc,
  • LAM-1,
  • LYAM1,
  • Lyam-1,
  • SELL,
  • lymphocyte adhesion molecule 1,
  • TQ1,
  • gp90-MEL,
  • Lymph node homing receptor,
  • LAM1,
  • L-selectin,
  • LECAM1,


From NCBI Gene and UniProtKB/Swiss-Prot: sL-selectin, also known as SELL, is a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. SELL mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes and promotes initial tethering and rolling of leukocytes in endothelia, facilitating their migration into secondary lymphoid organs and inflammation sites. SELL contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. Alternatively spliced transcript variants have been found for this gene.


There are no datasets associated with this biomarker.

QA State: Curated
Type: Protein

The following organs have data associated with this biomarker…


Phase: One
QA State: Under Review


No additional data available.

Performance Comment

SELL is a member of a 28 autoantibody (AAb) classifier that was developed with a sensitivity of 80.8% and a specificity of 61.6% (AUC=0.756). The 28 autoantibodies are potential biomarkers for breast cancer both individually and as members of the classifier.


Phase: Two
QA State: Curated


SELL has not been identified previously in serum as a lung cancer biomarker and represents a novel finding in the aptamer proteomic technology study (Ostroff et al, 2010). A decreased level of SELL was seen in the serum of lung cancer patients compared to controls in this study.

Performance Comment

sL-selectin, also known as SELL, is a member of a 12 protein panel that can discriminate NSCLC from controls with 91% sensitivity and 84% specificity in cross-validated training and 89% sensitivity and 83% specificity in a separate verification set, with similar performance for early and late stage NSCLC.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.