Early Detection Research Network

SLAMF8

Aliases:
This biomarker is also known as:
  • CD353,
  • B-lymphocyte activator macrophage expressed,
  • SLAM family member 8,
  • SLAMF8,
  • Q9P0V8,
  • CD353 antigen,
  • B lymphocyte activator macrophage expressed,
  • BLAME,
  • BCM-like membrane protein,
  • SBBI42,

Description…

SLAMF8 is a membrane protein belonging to the CD2 family of cell surface proteins. This protein family is characterized by Ig domains. SLAMF8 is expressed in lymph node, spleen, thymus and bone marrow. SLAMF8 may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor. There are two isoforms of this protein, produced by alternative splicing.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: SLAMF8

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Under Review

Overview

BLAME expression was absent in HUVEC (human umbilical vein endothelial cells) and tumor endothelial cells, but expression was detected in tumor leukocytes as well as normal monocytes.

Performance Comment

SLAMF8 (BLAME) was one of 13 genes out of 50 selected for further validation in PMID:21617380. SLAMF8 (BLAME) shows its highest levels of expression in tonsil and lung tissue and therefore could be suitable for abdominal imaging.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.