Early Detection Research Network

SLC11A1

Aliases:
This biomarker is also known as:
  • NRAMP1,
  • solute carrier family 11 (sodium/phosphate symporters), member 1,
  • SLC11A1,
  • LSH,
  • NRAMP 1,
  • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1,
  • natural resistance-associated macrophage protein 1,
  • NRAMP,
  • P49279,

Description…

SLC11A1 is a membrane associated divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. SLC11A1 is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family. Mutations in the SLC11A1 gene are involved in susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Several alternatively spliced variants have been identified.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: SLC11A1

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Under Review

Overview

NRAMP expression was absent in HUVEC (human umbilical vein endothelial cells) and tumor endothelial cells, but expression was detected in tumor leukocytes as well as normal monocytes.

Performance Comment

SLC11A1 (NRAMP) was one of 13 genes out of 50 selected for further validation in PMID:21617380.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.