Early Detection Research Network

Somalogic 12-marker panel for lung cancer

Aliases:
This biomarker is also known as:
  • Somalogic 12-marker panel for lung cancer,
  • Aptamer-based markers,
  • Ostroff 12-marker panel for lung cancer,

Description…

The sensitivity and specificity of our 12-biomarker panel improves upon published protein and gene expression panels. The 12-protein panel consists of cadherin-1 (CDH1), CD30 ligand (TNFSF8), endostatin, HSP90a, LRIG3, MIP-4 (CCL18), pleiotrophin, PRKCI, RGM-C (HFE2), SCF-sR (KIT), sL-selectin (SELL), and YES. The panel discriminates NSCLC from controls with 91% sensitivity and 84% specificity in cross-validated training and 89% sensitivity and 83% specificity in a separate verification set, with similar performance for early and late stage NSCLC.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
HGNC Name:

Panel Details

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Curated

Overview

This study identified 44 potential lung cancer biomarkers that discriminate stages I-III NSCLC cases from at-risk heavy smoker controls. The top performing classifier panel was composed of the 12 markers in this panel.

Performance Comment

The sensitivity and specificity of our 12-biomarker panel improves upon published protein and gene expression panels. The 12-protein panel coonsists of cadherin-1, CD30 ligand, endostatin, HSP90a, LRIG3, MIP-4, pleiotrophin, PRKCI, RGM-C, SCF-sR, sL-selectin, and YES. The panel discriminates NSCLC from controls with 91% sensitivity and 84% specificity in cross-validated training and 89% sensitivity and 83% specificity in a separate verification set, with similar performance for early and late stage NSCLC.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.

No other associated resources found.