Early Detection Research Network

ST14

Aliases:
This biomarker is also known as:
  • Q9Y5Y6,
  • OTTHUMP00000230932,
  • Matriptase,
  • EC 3.4.21,
  • prostamin,
  • tumor associated differentially expressed gene 15 protein,
  • suppressor of tumorigenicity 14 protein,
  • Serine protease TADG-15,
  • MTSP1,
  • TMPRSS14,
  • Serine protease 14,
  • Tumor-associated differentially-expressed gene 15 protein,
  • suppression of tumorigenicity 14 (colon carcinoma),
  • PRSS14,
  • Membrane-type serine protease 1,
  • ST14,
  • suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin),
  • HAI,
  • EC 3.4.21.109,
  • OTTHUMP00000230931,
  • TADG15,
  • MT-SP1,
  • Prostamin,
  • SNC19,

Description…

ST14 protein is an epithelial-derived, integral membrane serine protease and is found to be activated by sphingosine 1-phosphate. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: ST14

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Under Review

Overview

ST14 localized to vascular-like structures in ovarian cancer but not in normal ovaries.

Performance Comment

ST14 was one of 13 genes out of 50 selected for further validation in PMID:21617380. Average expression of ST14 was significantly higher in epithelial ovarian cancer tumors than any other normal tissue tested.

Attributes

Phase:
QA State:

Overview

Performance Comment

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.