Early Detection Research Network


This biomarker is also known as:
  • STAT6B,
  • transcription factor IL-4 STAT,
  • IL-4-STAT,
  • STAT6,
  • signal transducer and activator of transcription 6, interleukin-4 induced,
  • signal transducer and activator of transcription 6,
  • D12S1644,
  • STAT6C,
  • IL-4 Stat,
  • STAT, interleukin4-induced,


STAT6 is a member of the STAT family of transcription factors. STAT family members are phosphorylated by the receptor associated kinases in response to cytokines and growth factors and are involved in signal transduction and activation of transcription. There are several transcript variants produced by alternative splicing.


There are no datasets associated with this biomarker.

QA State: Curated
Type: Protein

The following organs have data associated with this biomarker…


Phase: Two
QA State: Under Review


The transcription factor STAT6 is a member of a family of DNA binding proteins. STAT6 has been shown to be a critical cell differentiation modulator in breast cancer cells.

Performance Comment

STAT6 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.