Early Detection Research Network

TAC1

Aliases:
This biomarker is also known as:
  • neuropeptide gamma,
  • PPT,
  • NPK,
  • tachykinin, precursor 1,
  • tachykinin-1,
  • Protachykinin-1,
  • substance P,
  • neurokinin alpha,
  • substance K,
  • neuromedin L,
  • TKN1,
  • neurokinin 1,
  • neurokinin 2,
  • neuropeptide K,
  • tachykinin,
  • TAC2,
  • NKNA,
  • TAC1,

Description…

The tachykinin gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These active peptides are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Multiple transcript variants encoding different isoforms have been found for this gene.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Accepted
Type: Genomic
HGNC Name: TAC1

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Accepted

Overview

Esophageal adenocarcinoma risk in Barrett's esophagus is increased 30- to 125- fold versus the general population. Among all Barrett's esophagus patients neoplastic progression occurs only once per 200 patient-years. Molecular markers (individual or in panel) would be useful to risk-stratify patients for more efficient surveillance endoscopy and to improve the early detection of progression.

Performance Comment

Promoter hypermethylation of TAC1 occurs early in both major types of human esophageal carcinoma, and is a potential biomarker of poor prognosis in esophageal squamous cell carcinoma. Studies are ongoing.

Supporting Study Data

The following studies/protocols provide evidence supporting TAC1 indications for the Esophagus…

No supporting studies or protocols found.

Organ-Specific Protocols

No organ-specific protocols defined.

Organ-Specific Publications

No organ-specific publications defined.

Organ-Specific Resources

No organ-specific resources defined.

No associated publications found.