Early Detection Research Network


This biomarker is also known as:
  • Trefoil Factor 3, HITF, Human Intestinal Trefoil Factor11,
  • HITF,
  • Trefoil Factor 3,
  • HP1.B,
  • Polypeptide P1.B,
  • TFF3,
  • ITF,
  • Trefoil Factor 3 (Intestinal),
  • Intestinal Trefoil Factor,
  • P1B,
  • TFI,


TFF3 is a member of the trefoil factor family. The trefoil factors are secreted peptides produced by normal intestinal mucosa, characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides.


There are no datasets associated with this biomarker.

QA State: Curated
Type: Gene

The following organs have data associated with this biomarker…


Phase: Two
QA State: Curated


Through gene expression profiling studies TFF3 mRNA has been found to be overexpressed in prostate cancer.

Performance Comment

Increased TFF3 transcript expression can be a predictor of prostate cancer. A multiplexed model including seven biomarkers (AMACR, ERG, GOLPH2, PCA3, SPINK1, TFF3, TMPRSS2:ERG) outperforms serum PSA or PCA3 alone.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.