Early Detection Research Network

TIMP1

Aliases:
This biomarker is also known as:
  • TIMP metallopeptidase inhibitor 1,
  • TIMP1,
  • Tissue inhibitor of metalloproteinases 1,
  • HCI,
  • EPO,
  • tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor),
  • TIMP,
  • CLGI,
  • TIMP-1,
  • metalloproteinase inhibitor 1,
  • Erythroid-potentiating activity,
  • Fibroblast collagenase inhibitor,
  • Collagenase inhibitor,

Description…

The TIMP1 protein encoded by this TIMP gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of the TIMP1 gene is highly inducible in response to many cytokines and hormones. Metalloproteinase 1 is a stromal factor with multiple functions. Overexpression reduces pancreatic cancer cell implantation, growth, metastasis, and angiogenesis, while increasing tumor apoptosis, all without altering metallopeptidase 2 production.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Protein
HGNC Name: TIMP1

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.