Early Detection Research Network

TLR2

Aliases:
This biomarker is also known as:
  • toll/interleukin-1 receptor-like protein 4,
  • toll-like receptor 2,
  • Toll/interleukin-1 receptor-like protein 4,
  • TLR2,
  • toll/interleukin 1 receptor-like 4,
  • TIL4,
  • CD282,
  • CD282 antigen,

Description…

TLR2, or toll-like receptor 2, is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2 is involved in the innate immune response to bacterial lipoproteins and other microbial cell wall components. TLR2 also plays a role in NF-kappa-B activation, cytokine secretion and the inflammatory response.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: TLR2

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Under Review

Overview

TLR2 gene polymorphisms have been related to increased susceptibility to cancer development in various organs, including breast cancer.

Performance Comment

TLR2 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.