Early Detection Research Network


This biomarker is also known as:
  • Tumor necrosis factor-inducible gene 6 protein,
  • tumor necrosis factor-stimulated gene-6 protein,
  • TNF alpha-induced protein 6,
  • TNFAIP6,
  • TSG6,
  • tumor necrosis factor, alpha-induced protein 6,
  • TNF-stimulated gene 6 protein,
  • TSG-6,
  • P98066,
  • Hyaluronate-binding protein,
  • tumor necrosis factor-inducible gene 6 protein,


TNFAIP6 is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. It is possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.


There are no datasets associated with this biomarker.

QA State: Curated
Type: Protein

The following organs have data associated with this biomarker…


Phase: Two
QA State: Under Review


TNFAIP6 (TSG6) localized to vascular-like structures in ovarian cancer but not in normal ovaries.

Performance Comment

TNFAIP6 (TSG6) was one of 13 genes out of 50 selected for further validation in PMID:21617380. Average expression of TNFAIP6 was significantly higher in epithelial ovarian cancer tumors than any other normal tissue tested.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.