Early Detection Research Network

TNFRSF1B

Aliases:
This biomarker is also known as:
  • TNFR1B,
  • TNFR-II,
  • INN=Etanercept,
  • TNF-R-II,
  • tumor necrosis factor binding protein 2,
  • TNFRSF1B,
  • p75TNFR,
  • p75,
  • CD120b antigen,
  • soluble TNFR1B variant 1,
  • TNFR80,
  • TNFr2,
  • tumor necrosis factor receptor superfamily, member 1B,
  • Tumor necrosis factor receptor 2,
  • TNFR2,
  • TBPII,
  • Etanercept,
  • tumor necrosis factor beta receptor,
  • TNF-RII,
  • TNF-R75,
  • CD_antigen=CD120b,
  • p80 TNF-alpha receptor,
  • TNFBR,
  • TNFri,
  • TNF-R2,
  • CD120b,
  • Tumor necrosis factor receptor type II,

Description…

TNFRSF1B, also known as TNFr2, a single-pass type I member of the TNF-receptor superfamily, forms a heterocomplex with TNF-receptor 1 that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Although the function of IAPs in TNF-receptor signalling is unknown, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest that TNFr2 plays a role in protecting neurons from apoptosis by stimulating antioxidative pathways.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Protein
HGNC Name: TNFRSF1B

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.