Early Detection Research Network


This biomarker is also known as:
  • DR6,
  • CD_antigen=CD358,
  • death receptor 6,
  • TNFRSF21,
  • UNQ437/PRO868,
  • tumor necrosis factor receptor superfamily, member 21,


TNFRSF21, a member of the TNF-receptor superfamily and a single-pass type I membrane protein, has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. TNFRSF21 is required for both normal cell body death and axonal pruning. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation.


There are no datasets associated with this biomarker.

QA State: Curated
Type: Protein

The following organs have data associated with this biomarker…


Phase: Three
QA State: Under Review


TNFRSF21 is a secreted molecule that is selectively expressed in tumor vasculature and represents a promising target as a serum biomarker.

Performance Comment

TNFRSF21 protein is detectable in sera of epithelial ovarian cancer patients and at higher levels compared with healthy donors.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.