Early Detection Research Network

TP63

Aliases:
This biomarker is also known as:
  • p73H,
  • TP63,
  • Transformation-related protein 63,
  • SHFM4,
  • CUSP,
  • tumor protein p63 deltaN isoform delta,
  • P63,
  • tumor protein p53-competing protein,
  • KET,
  • LMS,
  • B(p51A),
  • EEC3,
  • p40,
  • tumor protein p63,
  • Tumor protein p73-like,
  • tumor protein 63,
  • Chronic ulcerative stomatitis protein,
  • amplified in squamous cell carcinoma,
  • Keratinocyte transcription factor KET,
  • p51,
  • RHS,
  • AIS,
  • p53CP,
  • p73L,
  • TP73L,
  • TP53L,
  • p63,
  • OFC8,
  • B(p51B),
  • tumor protein p53-like,
  • NBP,
  • P73L,
  • P73H,

Description…

TP63 is a member of the p53 family of transcription factors. It acts as a sequence specific DNA binding transcriptional activator or repressor. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. TP63 may be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. It is involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Gene
HGNC Name: TP63

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.